Sgroi G, Cordone L, Fornili S L
Nucleic Acids Res. 1975 Sep;2(9):1569-77. doi: 10.1093/nar/2.9.1569.
The repair of U.V. damages to DNA in B. subtilis cultures competent for genetic transformation has been studied. The comparison of survival curves for competent and non competent fractions shows that: i) excision repair is more effective in competent than in non competent bacteria; ii) recombination repair is more effective in non competent than in competent bacteria. These facts support the hypothesis that metabolic conditions and, very likely, DNA replication play a role in the regulation of the efficiency of the two different mechanisms of repair.
对枯草芽孢杆菌中可进行遗传转化的培养物中紫外线对DNA造成的损伤修复进行了研究。对感受态和非感受态部分的存活曲线比较表明:i)在感受态细菌中切除修复比在非感受态细菌中更有效;ii)在非感受态细菌中重组修复比在感受态细菌中更有效。这些事实支持了这样的假设,即代谢条件以及很可能还有DNA复制在调节两种不同修复机制的效率中起作用。