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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Parrott R F, Goode J A

AFRC Institute of Animal Physiology and Genetics Research, Cambridge Research Station, England.

Gen Pharmacol. 1993 Jan;24(1):101-3. doi: 10.1016/0306-3623(93)90017-r.

Intravenous morphine decreases cortisol and increases prolactin concentrations in male sheep whereas naloxone has the opposite effect. 2. In this investigation, the effects of intracerebroventricular injections of naloxone, morphine (mu agonist), dynorphin (kappa agonist) and DADLE (delta/mu agonist) on cortisol and prolactin release were investigated. 3. None of the drugs affected cortisol secretion. 4. Naloxone transiently decreased prolactin levels (P < 0.05). 5. All the opioids tended to enhance prolactin secretion and the highest dose (300 micrograms) of DADLE produced a significant (P < 0.007) sustained increase. 6. These results are consistent with the view that exogenous and endogenous opioids affect the pituitary to influence cortisol release in sheep but act also at the hypothalamic level to influence prolactin secretion.

静脉注射吗啡可降低雄性绵羊的皮质醇水平并升高催乳素浓度，而纳洛酮则有相反的作用。2. 在本研究中，研究了脑室内注射纳洛酮、吗啡（μ激动剂）、强啡肽（κ激动剂）和DADLE（δ/μ激动剂）对皮质醇和催乳素释放的影响。3. 这些药物均未影响皮质醇分泌。4. 纳洛酮使催乳素水平短暂下降（P<0.05）。5. 所有阿片类药物均倾向于增强催乳素分泌，DADLE的最高剂量（300微克）可产生显著（P<0.007）的持续升高。6. 这些结果与以下观点一致，即外源性和内源性阿片类药物影响垂体以影响绵羊的皮质醇释放，但也作用于下丘脑水平以影响催乳素分泌。

Parrott R F, Goode J A

AFRC Institute of Animal Physiology and Genetics Research, Cambridge Research Station, England.

Gen Pharmacol. 1993 Jan;24(1):101-3. doi: 10.1016/0306-3623(93)90017-r.

Intravenous morphine decreases cortisol and increases prolactin concentrations in male sheep whereas naloxone has the opposite effect. 2. In this investigation, the effects of intracerebroventricular injections of naloxone, morphine (mu agonist), dynorphin (kappa agonist) and DADLE (delta/mu agonist) on cortisol and prolactin release were investigated. 3. None of the drugs affected cortisol secretion. 4. Naloxone transiently decreased prolactin levels (P < 0.05). 5. All the opioids tended to enhance prolactin secretion and the highest dose (300 micrograms) of DADLE produced a significant (P < 0.007) sustained increase. 6. These results are consistent with the view that exogenous and endogenous opioids affect the pituitary to influence cortisol release in sheep but act also at the hypothalamic level to influence prolactin secretion.

静脉注射吗啡可降低雄性绵羊的皮质醇水平并升高催乳素浓度，而纳洛酮则有相反的作用。2. 在本研究中，研究了脑室内注射纳洛酮、吗啡（μ激动剂）、强啡肽（κ激动剂）和DADLE（δ/μ激动剂）对皮质醇和催乳素释放的影响。3. 这些药物均未影响皮质醇分泌。4. 纳洛酮使催乳素水平短暂下降（P<0.05）。5. 所有阿片类药物均倾向于增强催乳素分泌，DADLE的最高剂量（300微克）可产生显著（P<0.007）的持续升高。6. 这些结果与以下观点一致，即外源性和内源性阿片类药物影响垂体以影响绵羊的皮质醇释放，但也作用于下丘脑水平以影响催乳素分泌。