The effect of BE 2254 on the metabolic response stimulated by pyrogen in rabbits.

1. Thermoregulatory effector processes were investigated in rabbits after treatment with 1 and 2 micrograms/kg of lipopolysaccharide Escherichia coli (LPS). Both doses produced a fever reaction resulting from stimulation of the metabolic rate and heat conservation responses. 2. BE 2254 administered in feverish rabbits reduced the metabolic as well as pyretic activity produced by both doses of pyrogen. 3. It is suggested that stimulation of the thermoregulatory heat production which contributes to a febrile rise in body temperature is dependent on alpha 1-adrenoceptor mechanisms.