文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Pharmacology, Medical Academy, Gdańsk, Poland.

Gen Pharmacol. 1993 Jan;24(1):177-83. doi: 10.1016/0306-3623(93)90031-r.

Thermoregulatory effector processes were investigated in rabbits after treatment with 1 and 2 micrograms/kg of lipopolysaccharide Escherichia coli (LPS). Both doses produced a fever reaction resulting from stimulation of the metabolic rate and heat conservation responses. 2. BE 2254 administered in feverish rabbits reduced the metabolic as well as pyretic activity produced by both doses of pyrogen. 3. It is suggested that stimulation of the thermoregulatory heat production which contributes to a febrile rise in body temperature is dependent on alpha 1-adrenoceptor mechanisms.

用1微克/千克和2微克/千克的大肠杆菌脂多糖（LPS）处理兔子后，对其体温调节效应过程进行了研究。两种剂量均引发了因代谢率刺激和热量保存反应导致的发热反应。2. 给发热的兔子注射BE 2254可降低两种剂量致热原所产生的代谢及发热活性。3. 有观点认为，有助于体温发热性升高的体温调节性产热刺激依赖于α1-肾上腺素能受体机制。

Department of Pharmacology, Medical Academy, Gdańsk, Poland.

Gen Pharmacol. 1993 Jan;24(1):177-83. doi: 10.1016/0306-3623(93)90031-r.

Thermoregulatory effector processes were investigated in rabbits after treatment with 1 and 2 micrograms/kg of lipopolysaccharide Escherichia coli (LPS). Both doses produced a fever reaction resulting from stimulation of the metabolic rate and heat conservation responses. 2. BE 2254 administered in feverish rabbits reduced the metabolic as well as pyretic activity produced by both doses of pyrogen. 3. It is suggested that stimulation of the thermoregulatory heat production which contributes to a febrile rise in body temperature is dependent on alpha 1-adrenoceptor mechanisms.

用1微克/千克和2微克/千克的大肠杆菌脂多糖（LPS）处理兔子后，对其体温调节效应过程进行了研究。两种剂量均引发了因代谢率刺激和热量保存反应导致的发热反应。2. 给发热的兔子注射BE 2254可降低两种剂量致热原所产生的代谢及发热活性。3. 有观点认为，有助于体温发热性升高的体温调节性产热刺激依赖于α1-肾上腺素能受体机制。