Gagalo I T, Hać E E, Korolkiewicz K Z
Eur J Pharmacol. 1983 Dec 23;96(3-4):193-200. doi: 10.1016/0014-2999(83)90308-4.
The processes concerned with the production and loss of body heat in sodium salicylate or acetylsalicylic acid antipyresis were investigated in adult rabbits at an ambient temperature of 21.5 +/- 0.5 degrees C. The experimental fever elicited by i.v. injection of lipopolysaccharide Escherichia coli (1 microgram/kg) was accompanied by increases in O2 consumption and CO2 production as well as decreases in convective heat loss. Pretreatment with 200 mg/kg of sodium salicylate (an hour's i.v. infusion) or with the same dose of acetylsalicylic acid (per os) significantly reduced pyrogen fever but the magnitude of O2 consumption and CO2 production remained at least at the febrile level. In the case of sodium salicylate, the level was even exceeded. At the same time both salicylates activated heat dissipation as manifested by decreases in vasomotor tone and tachypnea. Thus, it is apparent that the antipyretic effect of salicylates may develop without the inhibition of heat production. Heat loss processes initiated by these drugs are responsible for the antipyresis.
在环境温度为21.5±0.5摄氏度的成年兔子身上，研究了水杨酸钠或乙酰水杨酸解热过程中与体温产生和散失相关的过程。静脉注射脂多糖大肠杆菌（1微克/千克）引发的实验性发热，伴随着耗氧量和二氧化碳生成量的增加以及对流散热的减少。用200毫克/千克的水杨酸钠（静脉输注一小时）或相同剂量的乙酰水杨酸（口服）进行预处理，可显著降低致热原性发热，但耗氧量和二氧化碳生成量至少仍维持在发热水平。就水杨酸钠而言，甚至超过了该水平。同时，两种水杨酸盐都通过血管运动张力降低和呼吸急促表现出激活散热作用。因此，很明显，水杨酸盐的解热作用可能在不抑制产热的情况下产生。这些药物引发的散热过程导致了解热作用。
