大鼠离体子宫对多巴胺激动剂的反应。

Response to dopamine agonists of the rat isolated uterus.

Estañ L, Berenguer A, Martinez-Mir I, Rubio E, Morales-Olivas F J

Departamento de Farmacología, Universitat de Valencia, Spain.

Gen Pharmacol. 1993 Mar;24(2):397-401. doi: 10.1016/0306-3623(93)90323-p.

Abstract

Quinpirole did not produce any effect in isolated uterus from oestrogenized rats even when it is contracted by KCl (37 mM). 2. Fenoldopam produced a relaxant effect on rat isolated uterus contracted by KCl which was not significantly modified by SCH 23390. 3. Reserpine decreased the effect of the lowest doses of fenoldopam. In reserpinized rats, propranolol (10(-9), 10(-8), 10(-7) M) antagonized the effect of the lowest doses of fenoldopam and neither SCH 23390, sulpiride nor ranitidine modified the effect of fenoldopam. 4. The results confirm our previous finding that DA1-receptors are not functional in our preparation. The effect of fenoldopam was partially due to a catecholamine-releasing action.

摘要

喹吡罗对雌激素化大鼠的离体子宫没有产生任何作用，即使该子宫已被37 mM氯化钾收缩。2. 非诺多泮对由氯化钾收缩的大鼠离体子宫产生松弛作用，且该作用未被SCH 23390显著改变。3. 利血平降低了最低剂量非诺多泮的作用。在利血平化大鼠中，普萘洛尔（10⁻⁹、10⁻⁸、10⁻⁷ M）拮抗最低剂量非诺多泮的作用，而SCH 23390、舒必利和雷尼替丁均未改变非诺多泮的作用。4. 结果证实了我们之前的发现，即DA1受体在我们的制备物中无功能。非诺多泮的作用部分归因于儿茶酚胺释放作用。