组蛋白对线粒体质子转运的抑制作用。

Histone inhibition of mitochondrial proton transport.

作者信息

Hillar M

出版信息

Arch Int Physiol Biochim. 1978 May;86(2):227-33. doi: 10.3109/13813457809069899.

Abstract

Histone blocks proton uptake by mitochondria incubated in the presence of valinomycin or DNP. In the presence of DNP valinomycin-induced H+ uptake is not affected by histone. H+ uptake induced by nigericin is not affected by histone as well. Postulated mechanism of histone action involves the immobilization of proton translocation in mitochondrial membrane and induction of local change in H+ concentration, the prevention of the interaction between H+ and natural K+-carrier and Mg2+ transport system or valinomycin.

摘要

组蛋白可阻止在缬氨霉素或二硝基酚（DNP）存在的情况下线粒体对质子的摄取。在DNP存在时，缬氨霉素诱导的H⁺摄取不受组蛋白影响。尼日利亚菌素诱导的H⁺摄取也不受组蛋白影响。推测的组蛋白作用机制包括使线粒体内膜质子转运固定化并诱导H⁺浓度的局部变化，阻止H⁺与天然K⁺载体以及Mg²⁺转运系统或缬氨霉素之间的相互作用。