惊吓反应和前脉冲抑制中的胆碱能机制：假性胆碱能前体N-氨基乙醇的作用。
Cholinergic mechanisms in startle and prepulse inhibition: effects of the false cholinergic precursor N-aminodeanol.
作者信息
Wu M F, Jenden D J, Fairchild M D, Siegel J M
机构信息
Department of Veterans Affairs Medical Center, Sepulveda, California 91343.
出版信息
Behav Neurosci. 1993 Apr;107(2):306-16. doi: 10.1037//0735-7044.107.2.306.
Abstract
We examined the effects of cholinergic deficiency on prepulse inhibition (PPI) of the acoustic startle. Rats treated with a choline-free diet that contained the false cholinergic precursor N-aminodeanol showed great deficit in PPI. This deficit does not appear to be secondary to an increase of stereotyped behaviors. Startle threshold was also greatly reduced, as these rats startled to the 70-dB prepulse and the baseline startle amplitude was increased by 60% over the control rats. Arecoline (4 mg/kg) partially reversed the deficit in PPI. This improvement persisted beyond the period of drug treatment. On the other hand, scopolamine (1 mg/kg) reduced PPI in the control rats. These results suggest that cholinergic systems play a major role in both the elicitation and prepulse inhibition of startle.
摘要
我们研究了胆碱能缺乏对听觉惊吓前脉冲抑制（PPI）的影响。用不含胆碱但含有假胆碱能前体N-氨基乙醇的饮食处理的大鼠在PPI方面表现出极大的缺陷。这种缺陷似乎不是由刻板行为增加继发而来的。惊吓阈值也大大降低，因为这些大鼠对70分贝的前脉冲产生惊吓反应，且基线惊吓幅度比对照大鼠增加了60%。槟榔碱（4毫克/千克）部分逆转了PPI的缺陷。这种改善在药物治疗期之后仍然存在。另一方面，东莨菪碱（1毫克/千克）降低了对照大鼠的PPI。这些结果表明，胆碱能系统在惊吓的诱发和前脉冲抑制中都起主要作用。
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