O'Donnell P D, Hawkins W H
Department of Urology, University of Arkansas for Medical Sciences, Little Rock.
Urology. 1993 May;41(5):452-4. doi: 10.1016/0090-4295(93)90506-6.
Bethanechol has been shown to produce a pharmacologic effect on the urinary bladder, although the clinical efficacy of this response is controversial. The measured response has been an increase in detrusor pressure, although sensory effects may occur also. In this study, 10 neurologically intact men had cystometry before subcutaneous administration of 5 mg bethanechol chloride and thirty minutes after bethanechol. The sensation of desire to void and the maximum cystometric capacity occurred at a higher intravesical pressure and a smaller bladder capacity following bethanechol. Subcutaneous bethanechol appears to alter the bladder pressure and capacity at which the perception of desire to void and the sensation of maximum fullness occurs.
已证实氨甲酰甲胆碱可对膀胱产生药理作用，尽管这种反应的临床疗效存在争议。所测得的反应是逼尿肌压力增加，不过也可能出现感觉效应。在本研究中，10名神经功能正常的男性在皮下注射5毫克氯化氨甲酰甲胆碱前及注射后30分钟进行了膀胱测压。注射氨甲酰甲胆碱后，产生排尿欲望的感觉以及最大膀胱测压容量出现在更高的膀胱内压和更小的膀胱容量时。皮下注射氨甲酰甲胆碱似乎会改变产生排尿欲望的感觉和最大充盈感时的膀胱压力及容量。
