Mitchell W C, Venable D D
J Urol. 1985 Oct;134(4):791-4. doi: 10.1016/s0022-5347(17)47440-4.
Metoclopramide (Reglan) has been widely used as a motility agent because of its contractile effects on gastrointestinal smooth muscle. This agent also may demonstrate significant effects in the urinary system; however, controlled studies of possible effects on bladder function have not been previously reported. Metoclopramide effects on the detrusor smooth muscle were studied using a canine model system. Metoclopramide was compared with bethanechol chloride and a control substance in a random double blind study. Preliminary data from this animal model suggests that metoclopramide significantly increased detrusor contractility as manifested by a decrease in bladder capacity, an increase in detrusor peak voiding pressure and a decrease in post-void residual volume. These effects were similar to those manifested by parenteral bethanechol chloride.
甲氧氯普胺（胃复安）因其对胃肠道平滑肌的收缩作用而被广泛用作促动力剂。该药物在泌尿系统中也可能显示出显著作用；然而，此前尚未有关于其对膀胱功能可能影响的对照研究报道。使用犬模型系统研究了甲氧氯普胺对逼尿肌平滑肌的作用。在一项随机双盲研究中，将甲氧氯普胺与氯化贝胆碱及一种对照物质进行了比较。来自该动物模型的初步数据表明，甲氧氯普胺显著增加了逼尿肌收缩力，表现为膀胱容量减小、逼尿肌排尿峰值压力增加以及排尿后残余尿量减少。这些作用与胃肠外给予氯化贝胆碱所表现出的作用相似。
