Scott M P
Department of Developmental Biology, Stanford University School of Medicine, CA 94305-5427.
Nucleic Acids Res. 1993 Apr 25;21(8):1687-8. doi: 10.1093/nar/21.8.1687.
Developmental fates along the anterior-posterior axes of animals are controlled by clustered homeotic genes which in vertebrates are called Hox genes. The gene clusters are similar and probably functionally homologous in animals as different as nematodes, flies, and mammals. A new set of names for Hox genes was recently agreed upon by many workers in the field. Remarkably, the order of the Hox genes along the chromosome reflects where they are expressed along the body axis. This simple principle is reflected in the new nomenclature system.
动物前后轴上的发育命运由成簇的同源异型基因控制，在脊椎动物中这些基因被称为Hox基因。这些基因簇在诸如线虫、果蝇和哺乳动物等不同动物中是相似的，并且可能在功能上是同源的。该领域的许多研究人员最近商定了一套Hox基因的新命名。值得注意的是，Hox基因在染色体上的排列顺序反映了它们在身体轴上的表达位置。这一简单原则体现在新的命名系统中。
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