c-Harvey-Ras-1（HRAS-1）标志物与自闭症之间可能存在的关联。
Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism.
作者信息
Hérault J, Perrot A, Barthélémy C, Büchler M, Cherpi C, Leboyer M, Sauvage D, Lelord G, Mallet J, Müh J P
机构信息
National Institute for Health and Medical Research, Tours, France.
出版信息
Psychiatry Res. 1993 Mar;46(3):261-7. doi: 10.1016/0165-1781(93)90094-w.
We tested for an association between autism and genes coding for enzymes involved in monoaminergic metabolism and for a linked marker, c-Harvey-Ras-1 (HRAS 1), using restriction fragment length polymorphisms. We did not find evidence of an association between autism and genes coding for tyrosine hydroxylase, dopamine-beta-hydroxylase (DBH), and tryptophan hydroxylase. However, we report a positive association between autism and the locus containing the gene for HRAS-1.
我们利用限制性片段长度多态性，检测了自闭症与编码参与单胺能代谢的酶的基因以及一个连锁标记物——c-Harvey-Ras-1（HRAS 1）之间的关联。我们没有发现自闭症与编码酪氨酸羟化酶、多巴胺-β-羟化酶（DBH）和色氨酸羟化酶的基因之间存在关联的证据。然而，我们报告了自闭症与含有HRAS-1基因的基因座之间存在正相关。
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