抗LW的一个新例子及该系统异质性的进一步研究。

A new example of anti-LW and further studies on heterogeneity of the system.

作者信息

White J C, Rolih S, Wilkinson S L, Hatcher B J, Issitt P D

出版信息

Transfusion. 1975 Jul-Aug;15(4):368-72. doi: 10.1046/j.1537-2995.1975.15476034561.x.

DOI:10.1046/j.1537-2995.1975.15476034561.x

Abstract

A case is reported in which an LW3 woman formed anti-LW. It is shown that the case represents the "genetic" and not the "transient" type of red blood cell LW antigen depletion. Studies have confirmed the quantitative difference of LW antigen on LW3 and LW4 red blood cells and the fact that Rhnull individuals produce the only totally LW-negative red blood cells. The difficulties encountered in the identification of anti-LW, because of the LW3 and LW4 states, are described. It is clear, from this study, that if random donors are typed for LW using anti-LW made by an LW4 indvidual, those who are LW3 will be classed as unremarkable LW-positives.

摘要

报道了一例LW3型女性产生抗LW的病例。结果表明，该病例代表红细胞LW抗原缺失的“遗传”型而非“短暂”型。研究证实了LW3和LW4红细胞上LW抗原的数量差异，以及Rhnull个体产生唯一完全LW阴性红细胞这一事实。描述了由于LW3和LW4状态在鉴定抗LW时遇到的困难。从这项研究可以清楚地看出，如果使用LW4个体产生的抗LW对随机供者进行LW分型，LW3型的个体将被归类为普通的LW阳性。