一个有助于进一步深入了解LW血型系统的“新”等位基因。

A 'new' allele giving further insight into the LW blood group system.

作者信息

Sistonen P, Tippett P

出版信息

Vox Sang. 1982;42(5):252-5. doi: 10.1111/j.1423-0410.1982.tb00753.x.

DOI:10.1111/j.1423-0410.1982.tb00753.x

Abstract

Nea, a red cell antigen present in 6% of Finnish people but in less than 1% of other Europeans tested, is shown to be part of the LW system. Tests on 10,025 Finnish donors show the antithetical relationship of anti-Nea (proposed name anti-LWb) and anti-LW made by LW3 people (proposed name anti-LWa). Tests on families of previously reported LW3 propositi and of LW(a-b+) Finnish donors support the hypothesis that Nea (LWb) is an allele at the LW locus which when homozygous produces the phenotype once called LW3.

摘要

Nea是一种红细胞抗原，在6%的芬兰人中存在，但在接受检测的其他欧洲人中不到1%。研究表明，Nea是LW系统的一部分。对10,025名芬兰献血者的检测显示，LW3个体产生的抗-Nea（建议命名为抗-LWb）与抗-LW（建议命名为抗-LWa）呈对立关系。对先前报道的LW3先证者家族以及LW(a-b+)芬兰献血者家族的检测支持了以下假设：Nea（LWb）是LW基因座上的一个等位基因，纯合时会产生曾被称为LW3的表型。