一项家族研究揭示的LW血型分型困难。

Difficulty in LW typing as revealed by a family study.

作者信息

Behzad O, Pothiawala M, Rolih S D, Issitt P D, Lee C L

出版信息

Transfusion. 1978 Jul-Aug;18(4):488-92. doi: 10.1046/j.1537-2995.1978.18478251248.x.

DOI:10.1046/j.1537-2995.1978.18478251248.x

Abstract

A family is described in which two members of the second generation are of the phenotype LW3. In the course of the investigation the mother of the LW3 propositus was at first believed to be phenotypically LW3 as well. Eventually, it was shown that she is, in fact, phenotypically LW2 but that her R-1 (no D), LWlw, genotype had resulted in less LW being present on her red blood cells than is expected in LW2 persons. This reduced level of LW could not be detected with one example of anti-LW made by an LW3 individual.

摘要

本文描述了一个家族，其中第二代的两名成员表现为LW3表型。在调查过程中，LW3先证者的母亲起初也被认为表型为LW3。最终发现，她实际上表型为LW2，但她的R-1（无D）、LWlw基因型导致其红细胞上的LW抗原含量低于LW2个体的预期值。用一名LW3个体制备的一种抗-LW试剂无法检测到这种降低的LW水平。