Meyaard L, Schuitemaker H, Miedema F
Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Immunol Today. 1993 Apr;14(4):161-4. doi: 10.1016/0167-5699(93)90279-T.
Before CD4+ T cells are depleted, T cells in asymptomatic HIV-infected individuals are functionally abnormal. These T cells are programmed for death, are non-responsive and fail to produce interleukin-2 after antigenic stimulation. Our view is that these different T-cell abnormalities are explained by the effects of HIV on antigen-presenting cells. Alteration of the functions of the antigen-presenting cell may program T cells for activation-induced death, and may induce anergy in interleukin-2 and interferon-gamma secreting TH1 cells. This results in predominance of TH2 allergic responses instead of cellular immunity dependent on TH1 cells.
在CD4+ T细胞耗竭之前，无症状HIV感染个体中的T细胞功能异常。这些T细胞被编程死亡，无反应性，并且在抗原刺激后无法产生白细胞介素-2。我们认为，这些不同的T细胞异常是由HIV对抗抗原呈递细胞的作用所解释的。抗原呈递细胞功能的改变可能使T细胞被编程进行激活诱导的死亡，并可能在分泌白细胞介素-2和干扰素-γ的TH1细胞中诱导无反应性。这导致TH2过敏反应占主导，而不是依赖TH1细胞的细胞免疫。
