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与胆碱能功能降低相关的执行集延迟消退:一种持续性和侵入性行为的机制。

Delayed extinction of executive sets associated with decreased cholinergic function: a mechanism of perseverative and intrusive behavior.

作者信息

Galdi J A

机构信息

Comprehensive Neuropsychology Services, Wausau, WI 54401.

出版信息

Brain Cogn. 1993 May;22(1):1-18. doi: 10.1006/brcg.1993.1021.

DOI:10.1006/brcg.1993.1021
PMID:8098943
Abstract

Perseverative and intrusive behavior were studied in three psychiatric patients with toxic dementia associated with anticholinergic drugs. A mechanism was proposed attributing these behaviors to the delayed extinction (residual activation) of prior executive sets (or schema) in the context of sets containing nondissociated operations. Reutilization of these operations appeared to trigger the nonextinguished set back into executive status. It was hypothesized that set perseveration and intrusion reflect a defect in the set-scheduling process induced by loss of cholinergic function.

摘要

对三名患有与抗胆碱能药物相关的中毒性痴呆的精神病患者的持续性和侵入性 行为进行了研究。提出了一种机制,将这些行为归因于在包含非分离操作的集合背景下先前执行集(或图式)的延迟消退(残余激活)。这些操作的重新利用似乎会触发未消退的集合恢复到执行状态。据推测,集合持续性和侵入性反映了胆碱能功能丧失引起的集合调度过程中的缺陷。

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