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[针刺镇痛过程中延髓头端腹外侧网状结构内源性阿片肽含量的变化]

[Changes of endogenous opioid peptides content in RPGL during acupuncture analgesia].

作者信息

Zhou L, Jiang J W, Wu G C, Cao X D

机构信息

Department of Neurobiology, Shanghai Medical University.

出版信息

Sheng Li Xue Bao. 1993 Feb;45(1):36-43.

PMID:8099232
Abstract

By push-pull perfusion technique and RIA of neuro-peptides, it was found that after 20 minutes' electroacupunture (EA), the release of LEK from the RPGL in the EA group was significantly higher than that in the control group (P < 0.05). The release of beta-EP from the RPGL in the EA group with higher efficacy was significantly higher than that in the control group (P < 0.05), but no significant changes were found in the EA group with lower efficacy. There was a positive correlation between the changes of release of LEK or beta-EP and the increase of pain threshold. The release of DynA1-13 tends to show a barely significant extent (P > 0.05). The results indicate that acupuncture analgesia is able to increase the release of LEK and beta-EP in the RPGL.

摘要

采用推挽式灌注技术和神经肽放射免疫分析法发现,电针20分钟后,电针组延髓后外侧网状核(RPGL)中亮脑啡肽(LEK)的释放量显著高于对照组(P<0.05)。疗效较好的电针组RPGL中β-内啡肽(β-EP)的释放量显著高于对照组(P<0.05),但疗效较差的电针组未发现显著变化。LEK或β-EP释放量的变化与痛阈升高呈正相关。强啡肽A1-13(DynA1-13)的释放量变化趋势不显著(P>0.05)。结果表明,针刺镇痛能增加RPGL中LEK和β-EP的释放。

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