Monlun E, Zeller H, Le Guenno B, Traoré-Lamizana M, Hervy J P, Adam F, Ferrara L, Fontenille D, Sylla R, Mondo M
Institut Pasteur Dakar, Sénégal.
Bull Soc Pathol Exot. 1993;86(1):21-8.
A study about the circulation of arboviruses of medical interest in southeastern Senegal was conducted from 1988 to 1991, during and around the periods of transmission. Specific IgM antibodies were detected by ELISA test in human sera, as a sign of a recent infection within 2 to 5 months. The comparison of the serological IgM results from human surveys in different villages, and the isolations of arboviruses from mosquitoes during the same period of time permitted a rapid and global evaluation of the circulation of these viruses. A low level of yellow fever virus activity was detected both in humans and mosquitoes in 1988 to 1990. A dengue 2 epizootic occurred in 1989-1990. Dengue 2 virus was isolated from humans and mosquitoes in 1990. Some dengue 2 outbreak may occur in the upcoming years. A Zika virus epizootic outbreak was observed each year. A human strain was isolated in 1990. The other flaviviruses (West-Nile, Kedougou, Wesselsbron), Chikungunya virus, Rift Valley Fever virus and Crimean-Congo Hemorrhagic Fever virus did not seem to present a major public health concern in southeastern Senegal.
1988年至1991年期间，在塞内加尔东南部蚊虫传播期间及前后，开展了一项关于具有医学意义的虫媒病毒传播情况的研究。通过酶联免疫吸附测定（ELISA）检测人血清中的特异性IgM抗体，作为2至5个月内近期感染的标志。对不同村庄人群调查的血清学IgM结果进行比较，以及在同一时期从蚊子中分离虫媒病毒，有助于快速全面评估这些病毒的传播情况。1988年至1990年期间，在人和蚊子中均检测到低水平的黄热病毒活动。1989 - 1990年发生了登革2型动物疫情。1990年从人和蚊子中分离出登革2型病毒。未来几年可能会发生一些登革2型疫情。每年都观察到寨卡病毒动物疫情爆发。1990年分离出一株人源毒株。其他黄病毒（西尼罗河病毒、凯杜古病毒、韦塞尔斯布朗病毒）、基孔肯雅病毒、裂谷热病毒和克里米亚 - 刚果出血热病毒在塞内加尔东南部似乎并未构成重大公共卫生问题。
