Gonzalez D L, Fuchs J L, Droge M H
Department of Biology, Texas Woman's University, Denton 76204.
Neurosci Lett. 1993 Mar 19;151(2):134-7. doi: 10.1016/0304-3940(93)90004-5.
The role of NMDA receptors in spinal sensorimotor processes has been studied in neonates and adults, while NMDA binding has previously been described only in mature spinal cord. In autoradiographs of mouse lumbar cord, NMDA-sensitive [3H]glutamate binding peaked transiently around postnatal days 6-10. Differentiation increased progressively from day 10 to adulthood. Mature levels were highest in substantia gelatinosa and moderate in dorsomedial dorsal horn. The results are described in relation to functional and anatomical features of developing spinal cord.
N-甲基-D-天冬氨酸（NMDA）受体在脊髓感觉运动过程中的作用已在新生儿和成人中进行了研究，而此前仅在成熟脊髓中描述过NMDA结合情况。在小鼠腰髓的放射自显影片中，NMDA敏感的[3H]谷氨酸结合在出生后第6至10天左右短暂达到峰值。从第10天到成年期，分化逐渐增加。成熟水平在脊髓胶状质中最高，在背内侧背角中中等。结合发育中脊髓的功能和解剖特征对结果进行了描述。
