Cesková E, Svestka J, Rysánek R
Psychiatrická klinika LF MU, Brno.
Cesk Psychiatr. 1993 Jan;89(1):11-4.
In an open intraindividual comparison of haloperidol and oxyprothepine decanoates there was a tendency in favour of haloperidol decanoate. At the end of 9 months' maintenance treatment there were no statistically significant differences in the global BPRS score, CGI and individual BPRS items with exception of paranoidity. No differences in the occurrence of rehospitalizations and ambulatory relapses were found. As for side effects with haloperidol decanoate a higher occurrence of akathisia and a lower mean weigh increase (2 kg v. 4 kg) were observed and twice more pts had no side effects in comparison with oxyprothepine decanoate, but also these differences were not statistically significant. Taking into consideration the differences found (even if not statistically significant) and the individual reactivity, it seems to us advantageous to have a broader choice of depot neuroleptics.
在一项关于氟哌啶醇癸酸酯和奥昔丙嗪癸酸酯的开放性个体内比较中，有倾向支持氟哌啶醇癸酸酯。在9个月的维持治疗结束时，除偏执狂外，总体BPRS评分、CGI和个体BPRS项目均无统计学显著差异。在再次住院和门诊复发的发生率方面未发现差异。至于氟哌啶醇癸酸酯的副作用，观察到静坐不能的发生率较高，平均体重增加较低（2千克对4千克），与奥昔丙嗪癸酸酯相比，无副作用的患者是其两倍，但这些差异也无统计学显著性。考虑到所发现的差异（即使无统计学显著性）和个体反应性，我们认为有更广泛的长效抗精神病药物选择是有利的。
