Berth-Jones J, Graham-Brown R A
Department of Dermatology, Leicester Royal Infirmary, UK.
Lancet. 1993 Jun 19;341(8860):1557-60. doi: 10.1016/0140-6736(93)90697-f.
Treatment of atopic dermatitis with essential fatty acids remains controversial. A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to receive evening primrose oil, evening primrose oil and fish oil, or placebo for 16 weeks. Disease activity was monitored by clinical severity scores recorded by the investigator, topical steroid requirement, and symptom scores recorded by subjects. Of 123 subjects recruited, 102 completed the treatment period. No improvement with active treatment was demonstrated. Our study, which avoided the methodological and analytical problems of previous studies, found no effect of essential fatty acid supplementation in atopic dermatitis.
用必需脂肪酸治疗特应性皮炎仍存在争议。开展了一项双盲、安慰剂对照、平行组研究，以调查特应性皮炎患者对必需脂肪酸补充剂的反应。特应性皮炎患者被随机分为接受月见草油、月见草油和鱼油或安慰剂治疗16周。通过研究者记录的临床严重程度评分、局部类固醇需求以及受试者记录的症状评分来监测疾病活动。在招募的123名受试者中，102名完成了治疗期。未显示积极治疗有改善效果。我们的研究避免了既往研究中的方法学和分析问题，发现补充必需脂肪酸对特应性皮炎没有效果。
