Man George, Hu Li-Zhi, Elias Peter M, Man Mao-Qiang
Dermatology Services, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, CA, 94121, USA.
School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Chin J Integr Med. 2018 Apr;24(4):308-314. doi: 10.1007/s11655-017-2769-1. Epub 2017 Sep 1.
Although a variety of regimens are available for the treatment of atopic dermatitis (AD), severe adverse reactions and unpopular costs often limit their usage. In contrast, certain inexpensive, naturally-occurring ingredients are proven effective for AD with fewer side effects. The beneficial effects of these ingredients can be attributed to inhibition of cytokine and chemokine expression, IgE production, inflammatory cell infiltration, histamine release, and/or the enhancement of epidermal permeability barrier function. Since herbal medicines are widely available, inexpensive and generally safe, they could be valuable alternatives for the treatment of AD, particularly for those patients who are not suitable for the utilization of immune modulators. In this review, we summarize the therapeutic benefits of natural ingredients for the treatment of AD and the mechanisms of their actions.
尽管有多种方案可用于治疗特应性皮炎（AD），但严重的不良反应和高昂的费用常常限制了它们的使用。相比之下，某些廉价的天然成分已被证明对AD有效，且副作用较少。这些成分的有益作用可归因于对细胞因子和趋化因子表达、IgE产生、炎症细胞浸润、组胺释放的抑制，和/或表皮通透性屏障功能的增强。由于草药广泛可得、价格低廉且通常安全，它们可能是治疗AD的有价值的替代方法，特别是对于那些不适合使用免疫调节剂的患者。在本综述中，我们总结了天然成分治疗AD的益处及其作用机制。
