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患有红细胞葡萄糖-6-磷酸脱氢酶缺乏症的新生儿的触珠蛋白、血红素结合蛋白、血红蛋白和血细胞比容

Haptoglobin, hemopexin, hemoglobin and hematocrit in newborns with erythrocyte glucose-6-phosphate dehydrogenase deficiency.

作者信息

Meloni T, Costa S, Cutillo S

出版信息

Acta Haematol. 1975;54(5):284-8. doi: 10.1159/000208087.

DOI:10.1159/000208087
PMID:809968
Abstract

Hemolysis was studied in 40 G-6-PD-deficient newborn infants, half of whom had bilirubin blood levels within the normal range whereas the others, who were hyperbilirubinemic, underwent exchange transfusion. Hemoglobin, hematocrit, hemopexin and haptoglobin showed no or little differences between either of the two groups and the controls. The findings confirm the authors' assumption expressed elsewhere that this form of hyperbilirubinemia is not hemolytic in nature.

摘要

对40名葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏的新生儿进行了溶血研究,其中一半婴儿的胆红素血水平在正常范围内,而另一半患有高胆红素血症的婴儿接受了换血治疗。两组婴儿与对照组相比,血红蛋白、血细胞比容、血红素结合蛋白和触珠蛋白均无差异或差异很小。这些发现证实了作者在其他地方表达的假设,即这种高胆红素血症本质上不是溶血性的。

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Haptoglobin, hemopexin, hemoglobin and hematocrit in newborns with erythrocyte glucose-6-phosphate dehydrogenase deficiency.患有红细胞葡萄糖-6-磷酸脱氢酶缺乏症的新生儿的触珠蛋白、血红素结合蛋白、血红蛋白和血细胞比容
Acta Haematol. 1975;54(5):284-8. doi: 10.1159/000208087.
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[Haptoglobin and hemopexin in glucose-6-phosphate dehydrogenase deficiency].[葡萄糖-6-磷酸脱氢酶缺乏症中的触珠蛋白和血红素结合蛋白]
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[HEMOGLOBIN, METHEMALBUMIN AND HAPTOGLOBINEMIA IN PLASMA OF NEWBORNS WITH HEMOLYTIC JAUNDICE DUE TO ERYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY. ELECTROPHORETIC RESEARCH].
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引用本文的文献

1
Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns.G6PD缺乏的非洲新生儿脐带血中的氧化应激标志物。
PLoS One. 2017 Feb 24;12(2):e0172980. doi: 10.1371/journal.pone.0172980. eCollection 2017.
2
Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia.吉尔伯特综合征与葡萄糖-6-磷酸脱氢酶缺乏症:对新生儿高胆红素血症至关重要的剂量依赖性基因相互作用。
Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12128-32. doi: 10.1073/pnas.94.22.12128.
3
Multiple glucose 6-phosphate dehydrogenase-deficient variants correlate with malaria endemicity in the Vanuatu archipelago (southwestern Pacific).
多种葡萄糖-6-磷酸脱氢酶缺乏变体与瓦努阿图群岛(西南太平洋)的疟疾流行情况相关。
Am J Hum Genet. 1995 Jan;56(1):294-301.