用于造血干细胞移植的脐带血库。
Cord blood banking for hematopoietic stem cell transplantation.
作者信息
Gluckman E
机构信息
Bone Marrow Transplant Unit, Hôpital Saint Louis, Paris, France.
出版信息
Nouv Rev Fr Hematol (1978). 1993 Feb;35(1):77-9.
The number of umbilical cord blood cells transplantation is increasing worldwide. The results are comparable to allogeneic bone marrow transplantation in a large variety of hematological diseases curable by bone marrow transplantation. The incidence of GVH has been so far limited. The advantages of using cord blood are related to the high number of hematopoietic progenitors in circulation at birth and to the relative immune reactivity of the new-born. A European cord blood bank project is described in order to obtain related or unrelated, matched or partially mismatched hematopoietic stem cell transplant for treating patients without a bone marrow donor.
全球范围内脐带血细胞移植的数量正在增加。在多种可通过骨髓移植治愈的血液疾病中，其结果与异基因骨髓移植相当。迄今为止，移植物抗宿主病（GVH）的发生率一直较低。使用脐带血的优势与出生时循环中造血祖细胞数量众多以及新生儿相对较低的免疫反应性有关。本文描述了一个欧洲脐带血库项目，目的是为没有骨髓供体的患者获取相关或不相关、匹配或部分不匹配的造血干细胞移植。
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