自体移植背景下干细胞检测与干细胞选择的新进展。
New developments in stem cell detection and stem cell selection in the context of autologous transplantations.
作者信息
Douay L, Lopez M, Giarratana M C, Bony V, Bouchet S, Gorin N C
机构信息
Unité de Recherche sur les greffes de cellules souches hématopoiétiques, CHU Saint Antoine, Paris, France.
出版信息
Nouv Rev Fr Hematol (1978). 1993 Feb;35(1):87-9.
The concept of bone marrow transplantation is now enlarged to hemopoietic stem cell transplantation. Basic research on hemopoiesis, its regulation and markers, allowed concrete progress in the field of autologous transplantation. We report two applications: 1) the improvement of methods for detection of stem cells, which ensure engraftment, using recombinant growth factors, allowed a more sensitive determination of chemotherapeutic in vitro treatments toxicity upon normal progenitor cells; 2) large scale selection of hemopoietic progenitor/stem cell using the CD 34 immunological marker: its application to autologous transplantation.
骨髓移植的概念现已扩大到造血干细胞移植。造血、其调节和标志物的基础研究使自体移植领域取得了具体进展。我们报告两项应用：1）利用重组生长因子改进干细胞检测方法，以确保植入，从而更灵敏地测定体外化疗对正常祖细胞的毒性；2）使用CD 34免疫标志物大规模筛选造血祖细胞/干细胞：其在自体移植中的应用。
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