Sfikakis P P, Tesar J, Baraf H, Lipnick R, Klipple G, Tsokos G C
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
Clin Immunol Immunopathol. 1993 Jul;68(1):88-92. doi: 10.1006/clin.1993.1100.
In view of recent data demonstrating increased expression of intercellular adhesion molecule-1 (ICAM-1) in the skin of patients with systemic sclerosis (SSc) we studied whether levels of soluble ICAM-1 (s-ICAM-1) shed into the circulation are increased in patients with this disorder. We also compared blood levels of s-ICAM-1 in SSc with those in systemic lupus erythematosus (SLE) and we investigated any possible association of s-ICAM-1 with soluble IL-2 receptor (s-IL 2R) levels, the latter being considered as a marker of lymphocyte activation. Patients with SSc had increased levels of sICAM-1 compared with healthy control subjects (mean +/- SEM, 587 +/- 34 versus 373 +/- 27 ng/ml, P < 0.0001). Patients with diffuse rapidly progressive disease had the highest s-ICAM-1 levels. No association was observed between the extent of skin or internal organ involvement and s-ICAM-1 levels. Patients with digital ulcers had significantly elevated s-ICAM-1, but not s-IL 2R, levels. No correlation was detected between individual s-ICAM-1 and S-IL 2R levels in SSc patients. These novel findings suggest that circulating s-ICAM-1 levels may be a useful marker of endothelial activation in SSc; however, further studies are needed to determine the role of ICAM-1 in the pathogenesis of this disorder.
鉴于最近的数据表明系统性硬化症（SSc）患者皮肤中细胞间黏附分子-1（ICAM-1）的表达增加，我们研究了该疾病患者循环中可溶性ICAM-1（s-ICAM-1）水平是否升高。我们还比较了SSc患者与系统性红斑狼疮（SLE）患者血液中s-ICAM-1的水平，并研究了s-ICAM-1与可溶性白细胞介素-2受体（s-IL 2R）水平之间的任何可能关联，后者被视为淋巴细胞活化的标志物。与健康对照受试者相比，SSc患者的sICAM-1水平升高（平均值±标准误，587±34对373±27 ng/ml，P<0.0001）。弥漫性快速进展性疾病患者的s-ICAM-1水平最高。未观察到皮肤或内脏器官受累程度与s-ICAM-1水平之间的关联。患有指端溃疡的患者s-ICAM-1水平显著升高，但s-IL 2R水平未升高。在SSc患者中，未检测到个体s-ICAM-1与S-IL 2R水平之间的相关性。这些新发现表明，循环中的s-ICAM-1水平可能是SSc患者内皮细胞活化的有用标志物；然而，需要进一步研究以确定ICAM-1在该疾病发病机制中的作用。
