Bistrian B R, Blackburn G L, Scrimshaw N S, Flatt J P
Am J Clin Nutr. 1975 Oct;28(10):1148-55. doi: 10.1093/ajcn/28.10.1148.
Adult protein-calorie malnutrition, as reflected by decreased levels of serum albumin and transferrin, was studied in 21 hospitalized patients. This malnutrition state was a consequence of a catabolic response to stress and also use of standard parenteral fluid maintenance with 5% dextrose and water. Associated findings included a significant reduction in both total lymphocytes and cellular immunity, as measured by dinitrochlorobenzene and Candida skin testing. This state of visceral attrition, resembling kwashiorkor, occurs commonly in hospitalized patients, and may account for significant morbidity and mortality. Alternatives to the 5% dextrose and water in the nutritional support of the semistarved state may allow better preservation of visceral protein status and immune function.
通过血清白蛋白和转铁蛋白水平降低反映出的成人蛋白质 - 热量营养不良，在21名住院患者中进行了研究。这种营养不良状态是对应激的分解代谢反应以及使用含5%葡萄糖和水的标准肠外补液维持治疗的结果。相关发现包括总淋巴细胞和细胞免疫功能均显著降低，这通过二硝基氯苯和念珠菌皮肤试验来测定。这种类似于夸希奥科病的内脏消耗状态在住院患者中很常见，可能是导致显著发病率和死亡率的原因。在半饥饿状态的营养支持中，替代5%葡萄糖和水的方案可能有助于更好地维持内脏蛋白质状态和免疫功能。
