Gulumian M, Casimiro E, Linder P W, Rama D B, Hancock R D
Department of Biochemistry, Department of National Health and Population Development, Johannesburg, Republic of South Africa.
Hum Exp Toxicol. 1993 May;12(3):247-51. doi: 10.1177/096032719301200308.
The Plasma Mobilizing Index parameters of the newly synthesized chelating agent THP-12-ane N4, determined by computer simulation studies, have indicated that this chelating agent might be a good antagonist for cadmium intoxication. Experiments conducted on rats confirmed this observation and showed that THP-12-ane N4 might have the ability to chelate and mobilize cadmium in vivo.
通过计算机模拟研究确定的新合成螯合剂THP - 12 - 环十四烷四胺的血浆动员指数参数表明，这种螯合剂可能是镉中毒的良好拮抗剂。在大鼠身上进行的实验证实了这一观察结果，并表明THP - 12 - 环十四烷四胺可能具有在体内螯合和动员镉的能力。
