Katagiri A, Tomita Y, Nishiyama T, Kimura M, Sato S
Department of Urology, Niigata University School of Medicine, Japan.
Br J Cancer. 1993 Jul;68(1):125-9. doi: 10.1038/bjc.1993.299.
P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours, which are more refractory than seminomas to anti-cancer chemotherapy, frequently expressed Pgp and GSTP1-1. Western blot analysis demonstrated lower amount of GSTP1-1 in seminoma than in teratoma. These results suggest that Pgp and GSTP1-1 might contribute to drug resistance in testis cancers.
P-糖蛋白（Pgp）和π类谷胱甘肽S-转移酶（GSTP1-1）被认为与多药耐药性相关。在免疫组织化学染色中，非精原细胞性生殖细胞肿瘤比精原细胞瘤对抗癌化疗更具难治性，且经常表达Pgp和GSTP1-1。蛋白质印迹分析表明，精原细胞瘤中的GSTP1-1含量低于畸胎瘤。这些结果表明，Pgp和GSTP1-1可能在睾丸癌的耐药性中起作用。
