人肺癌细胞系中谷胱甘肽S转移酶π信使核糖核酸的水平与对顺铂和卡铂的耐药性相关。
Levels of glutathione S transferase pi mRNA in human lung cancer cell lines correlate with the resistance to cisplatin and carboplatin.
作者信息
Nakagawa K, Yokota J, Wada M, Sasaki Y, Fujiwara Y, Sakai M, Muramatsu M, Terasaki T, Tsunokawa Y, Terada M
机构信息
Pharmacology Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1988 Mar;79(3):301-4. doi: 10.1111/j.1349-7006.1988.tb01590.x.
Abstract
The amounts of mRNA for glutathione S transferase pi (GST pi) were significantly lower in 3 human small cell lung cancer (SCLC) cell lines than in 3 non small cell lung cancer (NSCLC) cell lines. The sensitivities of the 3 SCLC cell lines to cisplatin and carboplatin were much higher than those of the 3 NSCLC cell lines. These results indicate that low levels of GST pi mRNA expression in SCLC cell lines inversely correlate to high sensitivity to cisplatin and carboplatin, and further suggest that GST pi may play an important role in intracellular inactivation of these drugs.
摘要
谷胱甘肽S转移酶pi（GST pi）的mRNA量在3种人小细胞肺癌（SCLC）细胞系中显著低于3种非小细胞肺癌（NSCLC）细胞系。3种SCLC细胞系对顺铂和卡铂的敏感性远高于3种NSCLC细胞系。这些结果表明，SCLC细胞系中低水平的GST pi mRNA表达与对顺铂和卡铂的高敏感性呈负相关，进一步表明GST pi可能在这些药物的细胞内失活中起重要作用。
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