Interleukin 12 in host defense against microbial pathogens.
作者信息
Locksley R M
机构信息
Department of Medicine, University of California San Francisco 94143-0654.
出版信息
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5879-80. doi: 10.1073/pnas.90.13.5879.
Abstract
摘要
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Interferon gamma inhibits interleukin 10 production by monocytes.
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Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6115-9. doi: 10.1073/pnas.90.13.6115.
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Recombinant interleukin 12 cures mice infected with Leishmania major.
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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
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Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3725-9. doi: 10.1073/pnas.90.8.3725.
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