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Interleukin 12 in host defense against microbial pathogens.

作者信息

Locksley R M

机构信息

Department of Medicine, University of California San Francisco 94143-0654.

出版信息

Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5879-80. doi: 10.1073/pnas.90.13.5879.

DOI:10.1073/pnas.90.13.5879
PMID:8100997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC46829/
Abstract
摘要

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Interleukin 12 in host defense against microbial pathogens.白细胞介素12在宿主抵御微生物病原体中的作用
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Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.在严重联合免疫缺陷（SCID）小鼠和C.B-17小鼠中，白细胞介素-12（IL-12）的中和作用会降低对李斯特菌的抵抗力。可通过γ干扰素（IFN-γ）逆转。
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[Symposium of mechanisms of host defense from fundamental and clinical medicine. 6. Expression of the host defense mechanism in the protection against microbial infections].[基础医学与临床医学宿主防御机制研讨会。6.宿主防御机制在抵御微生物感染中的表达]
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本文引用的文献

1
Interferon gamma inhibits interleukin 10 production by monocytes.干扰素γ抑制单核细胞产生白细胞介素10。
J Exp Med. 1993 Feb 1;177(2):523-7. doi: 10.1084/jem.177.2.523.
2
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.白细胞介素12是细胞内寄生虫不依赖T淋巴细胞诱导γ干扰素所必需的，并能在T细胞缺陷宿主中诱导抗性。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6115-9. doi: 10.1073/pnas.90.13.6115.
3
Recombinant interleukin 12 cures mice infected with Leishmania major.重组白细胞介素12可治愈感染硕大利什曼原虫的小鼠。
J Exp Med. 1993 May 1;177(5):1505-9. doi: 10.1084/jem.177.5.1505.
4
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.通过李斯特菌诱导的巨噬细胞产生的白细胞介素-12促使辅助性T细胞1（TH1）型CD4 + T细胞发育。
Science. 1993 Apr 23;260(5107):547-9. doi: 10.1126/science.8097338.
5
IL-12: initiation cytokine for cell-mediated immunity.白细胞介素-12：细胞介导免疫的起始细胞因子。
Science. 1993 Apr 23;260(5107):496-7. doi: 10.1126/science.8097337.
6
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.白细胞介素12和肿瘤坏死因子α是患李斯特菌病的重症联合免疫缺陷小鼠中自然杀伤细胞产生γ干扰素的共刺激因子，而白细胞介素10是一种生理性拮抗剂。
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3725-9. doi: 10.1073/pnas.90.8.3725.
7
IL-4 directs the development of Th2-like helper effectors.白细胞介素-4指导Th2样辅助效应细胞的发育。
J Immunol. 1990 Dec 1;145(11):3796-806.
8
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.体内和体外产生白细胞介素4（IL-4）的细胞：体外产生IL-4的细胞需要IL-2和IL-4。
J Exp Med. 1990 Sep 1;172(3):921-9. doi: 10.1084/jem.172.3.921.
9
Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens.细胞因子诱导巨噬细胞中氮氧化物的合成：宿主对利什曼原虫和其他细胞内病原体的保护性反应。
J Leukoc Biol. 1991 Jul;50(1):93-103. doi: 10.1002/jlb.50.1.93.
10
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.白细胞介素10（IL-10）抑制人单核细胞的细胞因子合成：单核细胞产生的IL-10的自身调节作用。
J Exp Med. 1991 Nov 1;174(5):1209-20. doi: 10.1084/jem.174.5.1209.