O'Sullivan C, Lewis C E, Harris A L, McGee J O
Department of Pathology and Bacteriology, John Radcliffe Hospital, Oxford, UK.
Lancet. 1993 Jul 17;342(8864):148-9. doi: 10.1016/0140-6736(93)91348-p.
By means of a cytokine release assay we have shown that in cell populations derived from primary breast carcinoma, epidermal growth factor (EGF) is secreted by cells with the characteristic morphological and immunophenotypic profile of activated macrophages (positive for CD68, CD16, CD25). EGF secretion was observed in 11 (31%) of 35 primary tumours. Secretion of EGF by normal or malignant epithelial cells was not observed. We found no association between EGF secretion by the primary tumour and recognised clinical indices of prognosis.
通过细胞因子释放试验，我们发现，在源自原发性乳腺癌的细胞群体中，表皮生长因子（EGF）由具有活化巨噬细胞特征性形态和免疫表型特征（CD68、CD16、CD25呈阳性）的细胞分泌。在35例原发性肿瘤中，有11例（31%）观察到EGF分泌。未观察到正常或恶性上皮细胞分泌EGF。我们发现原发性肿瘤分泌EGF与公认的预后临床指标之间无关联。
