α链病：免疫球蛋白异常、发病机制及当前概念
Alpha chain disease: immunoglobulin abnormalities, pathogenesis and current concepts.
作者信息
Seligmann M
出版信息
Br J Cancer Suppl. 1975 Mar;2:356-61.
Abstract
The laboratory findings upon which the diagnosis of alpha chain disease relies and the main results of immunochemical, structural and biosynthetic studies of the pathological immunoglobulin are reviewed briefly. The pathogenesis of the disease is discussed in view of its possibly non-malignant nature at the early stage and of its peculiar geographic distribution, suggesting the triggering role of an intestinal micro-organism.
摘要
简要回顾了α链病诊断所依据的实验室检查结果以及病理性免疫球蛋白的免疫化学、结构和生物合成研究的主要结果。鉴于该病早期可能具有的非恶性性质及其独特的地理分布，讨论了其发病机制，提示肠道微生物具有触发作用。
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Alpha chain disease: immunoglobulin abnormalities, pathogenesis and current concepts.α链病：免疫球蛋白异常、发病机制及当前概念
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本文引用的文献
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MALABSORPTION SYNDROME IN LYMPHOMA OF SMALL INTESTINE. A STUDY OF 13 CASES.小肠淋巴瘤中的吸收不良综合征。13例研究。
Isr J Med Sci. 1965 Mar;1:221-6.
2
Clinico-pathological study of a patient with "Mediterranean" type of abdominal lymphoma and a new type of IgA abnormality ("alpha chain disease").一名患有“地中海”型腹部淋巴瘤及新型IgA异常（“α链病”）患者的临床病理研究
Digestion. 1968;1(6):321-36. doi: 10.1159/000196874.
3
[A further case of alpha chain disease in a Eurasian].[一名欧亚混血儿的另一例α链病病例]
Ann Med Interne (Paris). 1970 Feb;121(2):135-48.
4
The pathology of so-called Mediterranean abdominal lymphoma with malabsorption.所谓伴有吸收不良的地中海腹部淋巴瘤的病理学
Cancer. 1972 Jun;29(6):1502-11. doi: 10.1002/1097-0142(197206)29:6<1502::aid-cncr2820290614>3.0.co;2-o.
5
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6
Immunochemical studies in four cases of alpha chain disease.4例α链病的免疫化学研究
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J Mol Biol. 1970 May 14;49(3):577-88. doi: 10.1016/0022-2836(70)90282-2.
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