大鼠十二指肠非肾上腺素能非胆碱能抑制性传递的调节：阿片类药物和5-羟色胺的作用
Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum: role of opiates and 5-hydroxytryptamine.
作者信息
Postorino A, Serio R, Mulè F, Adamo E B, Di Giovanni G, Marini R
机构信息
Dipartimento di Biologia Cellulare e dello Sviluppo, Corso Tukory, Palermo, Italia.
出版信息
Arch Ital Biol. 1993 Apr;131(2-3):235-43.
In rat duodenal segments in vitro, electrical field stimulation induced a TTX-sensitive relaxation in the presence of atropine and guanethidine. A correlation between the amplitude of the evoked response and stimulus frequency was observed. Opioid peptides DAGO, DPDPE and DYN caused a dose-dependent increase in the amplitude of the response to EFS. Naloxone shifted to the right the dose-response curves for each opioid peptide significantly enhancing the ED50 values. The amplitude of the response to EFS was enhanced, dose-dependently, also in the presence of 5-HT. Such an effect induced by 5-HT was prevented by 5-HT receptor desensitization, but persisted unchanged after naloxone pretreatment. Opioids failed to affect the response to EFS after 5-HT receptor desensitization. Results suggest that in rat duodenum opioids modulate NANC inhibitory neurotransmission, indirectly the release of 5-HT.
在体外培养的大鼠十二指肠段中，电场刺激在阿托品和胍乙啶存在的情况下诱导了一种对河豚毒素敏感的舒张反应。观察到诱发反应的幅度与刺激频率之间存在相关性。阿片肽DAGO、DPDPE和强啡肽导致对电场刺激反应的幅度呈剂量依赖性增加。纳洛酮使每种阿片肽的剂量-反应曲线向右移动，显著提高了半数有效剂量（ED50）值。在5-羟色胺（5-HT）存在的情况下，对电场刺激的反应幅度也呈剂量依赖性增强。5-HT受体脱敏可阻止5-HT诱导的这种效应，但在纳洛酮预处理后该效应保持不变。5-HT受体脱敏后，阿片类药物未能影响对电场刺激的反应。结果表明，在大鼠十二指肠中，阿片类药物调节非肾上腺素能非胆碱能（NANC）抑制性神经传递，间接调节5-HT的释放。
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