Passarelli F, Orzi F
Department of Neurosciences, University of Rome La Sapienza, Italy.
Neuroreport. 1993 Sep;4(9):1108-10.
We investigated the influence of electroconvulsive shock treatment on the opioid-mediated inhibition of serotonin (5-HT) release. The overflow of [3H]serotonin elicited by high potassium (30 mM) in superfused slices of rat hippocampus was significantly inhibited in the presence of two agonists, mu-selective [D-Ala2,N-methyl-Phe4,Gly5ol]enkephalin (DAGO) and delta-selective [D-Pen2,D-Pen5]enkephalin (DPDPE) in control animals. The repeated (once daily for 7 days) electroconvulsive shock treatment significantly reversed the inhibitory effect of both DAGO and DPDPE. Single electroconvulsive shock (1 day) had no effect on DAGO inhibition, on the contrary a trend to antagonism of the DPDPE effect was reported. These results suggested that the opioids are associated with the experimental induced seizures and that the ECS treatment might regulate the serotonin release throughout the opioid receptor system.
我们研究了电休克治疗对阿片类物质介导的5-羟色胺（5-HT）释放抑制作用的影响。在对照动物中，两种激动剂，μ-选择性[D-丙氨酸2，N-甲基苯丙氨酸4，甘氨酸5醇]脑啡肽（DAGO）和δ-选择性[D-青霉胺2，D-青霉胺5]脑啡肽（DPDPE）存在时，高钾（30 mM）诱发的大鼠海马灌流切片中[3H]5-羟色胺溢出受到显著抑制。重复（每天一次，共7天）电休克治疗显著逆转了DAGO和DPDPE的抑制作用。单次电休克（1天）对DAGO抑制作用无影响，相反，有报道称对DPDPE的作用有拮抗趋势。这些结果表明，阿片类物质与实验性诱发的癫痫发作有关，并且电休克治疗可能通过阿片受体系统调节5-羟色胺的释放。
