Pui C H, Luo X, Evans W, Martin S, Rugg A, Wilimas J, Crist W M, Hudson M
Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38101.
Blood. 1993 Aug 1;82(3):895-8.
Levels of soluble intercellular adhesion molecule-1 (ICAM-1) were measured in serum samples taken at diagnosis from pediatric patients with Hodgkin's disease (n = 69), acute lymphoblastic leukemia (n = 28), Wilms' tumor (n = 20), osteosarcoma (n = 17), rhabdomyosarcoma (n = 18), or Ewing's sarcoma (n = 15). Median levels of serum ICAM-1 were significantly higher in acute lymphoblastic leukemia and Hodgkin's disease than in controls and other malignancies. Levels were positively correlated with disease stage for patients with Hodgkin's disease, Ewing's sarcoma or Wilms' tumor, and with the frequency of relapse in Hodgkin's disease (P = .016). Serum levels were normal in all of 76 patients tested in remission. It remains to be determined whether increased serum ICAM-1 levels simply reflect a greater tumor burden or whether this molecule contributes directly to the progression of childhood malignancies.
在诊断时采集的儿科患者血清样本中，检测了可溶性细胞间黏附分子-1（ICAM-1）的水平。这些患者包括霍奇金淋巴瘤（n = 69）、急性淋巴细胞白血病（n = 28）、肾母细胞瘤（n = 20）、骨肉瘤（n = 17）、横纹肌肉瘤（n = 18）或尤因肉瘤（n = 15）。急性淋巴细胞白血病和霍奇金淋巴瘤患者血清ICAM-1的中位数水平显著高于对照组和其他恶性肿瘤患者。霍奇金淋巴瘤、尤因肉瘤或肾母细胞瘤患者的ICAM-1水平与疾病分期呈正相关，与霍奇金淋巴瘤的复发频率也呈正相关（P = 0.016）。76例处于缓解期的受试患者血清水平均正常。血清ICAM-1水平升高是仅仅反映了更大的肿瘤负荷，还是该分子直接促进儿童恶性肿瘤的进展，仍有待确定。
