细菌感染对普通鬣蜥（Agama agama）平均选定体温的影响：一项剂量反应研究。

The effect of bacteria infection on mean selected body temperature in the common Agama, agama agama: a dose-response study.

Ramos A B, Don M T, Muchlinski A E

Department of Biology, California State University, Los Angeles 90032.

Comp Biochem Physiol Comp Physiol. 1993 Jul;105(3):479-84. doi: 10.1016/0300-9629(93)90423-2.

Abstract

The fever response was studied in 43 common agamas using a self-pairing experiment in which animals received an intraperitoneal injection of sterile saline and an injection of one of six dosages of dead Aeromonas sobria (1 x 10(6), 1 x 10(7), 1 x 10(8), 1 x 10(9), 1 x 10(10), and 1 x 10(11) total organisms). 2. The results demonstrated a significant increase in Tb (1.6-3.1 degrees C) above the mean selected body temperature (MSBT) of the saline injection animals over a bacteria infection range of three orders of magnitude. At 1 x 10(8) organisms, an increase was observed on bacteria day 1 while at dosages of 1 x 10(9) and 1 x 10(10) an increase was observed on bacteria days 1 and 2. 3. At dosages of 1 x 10(6) and 1 x 10(7) there was no difference between saline MSBT and bacteria MSBT. 4. At a dosage of 1 x 10(11), MSBTs on bacteria days 1 and 2 were below saline MSBT. 5. The average duration of the fever response is related to the level of infection; however, the magnitude of the fever is relatively independent of the level of infection.

摘要

采用自配对实验对43只普通鬣蜥的发热反应进行了研究，在该实验中，动物接受腹腔注射无菌生理盐水以及六种剂量之一的死嗜水气单胞菌（总菌数分别为1×10⁶、1×10⁷、1×10⁸、1×10⁹、1×10¹⁰和1×10¹¹）注射。2. 结果表明，在三个数量级的细菌感染范围内，与注射生理盐水的动物的平均选定体温（MSBT）相比，体温（Tb）显著升高（1.6 - 3.1摄氏度）。在菌数为1×10⁸时，在细菌注射后第1天观察到体温升高，而在菌数为1×10⁹和1×10¹⁰时，在细菌注射后第1天和第2天观察到体温升高。3. 在菌数为1×10⁶和1×10⁷时，生理盐水组的MSBT与细菌注射组的MSBT之间没有差异。4. 在菌数为1×10¹¹时，细菌注射后第1天和第2天的MSBT低于生理盐水组的MSBT。5. 发热反应的平均持续时间与感染水平有关；然而，发热的幅度相对独立于感染水平。