法国菲尼斯泰尔省成年人群中的单克隆丙种球蛋白病。
Monoclonal gammopathies in the adult population of Finistère, France.
作者信息
Saleun J P, Vicariot M, Deroff P, Morin J F
出版信息
J Clin Pathol. 1982 Jan;35(1):63-8. doi: 10.1136/jcp.35.1.63.
Abstract
Three hundred and thirty-four monoclonal gammopathies were detected in the sera of 30 279 adults from Finistère. Monoclonal gammopathies (MG) are more common in Finistère than in Paris and their distribution is not homogeneous. IgG paraproteins are particularly common in the northeast of Finistère whereas IgM paraproteins are more common in the southwest. Family studies and the high degree of inbreeding would support the hypothesis that there is a genetic predisposition to develop MG but the occurrence of paraproteins among three non-consanguineous couples seems to favour the existence of an environmental factor.
摘要
在来自菲尼斯泰尔省的30279名成年人的血清中检测到334例单克隆丙种球蛋白病。单克隆丙种球蛋白病（MG）在菲尼斯泰尔省比在巴黎更常见，且其分布并不均匀。IgG副蛋白在菲尼斯泰尔省东北部尤为常见，而IgM副蛋白在西南部更为常见。家族研究和高度近亲繁殖支持存在患MG的遗传易感性这一假说，但在三对非近亲夫妇中出现副蛋白似乎支持环境因素的存在。
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