Tomimoto H, Akiguchi I, Akiyama H, Kimura J, Yanagihara T
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Am J Pathol. 1993 Aug;143(2):579-86.
We report here on T-cell infiltration and diffuse expression of the major histocompatibility complex (MHC) class II antigen in a heterogeneous group of macrophages and microglia in leukoencephalopathy (LE). Microglia reacting positively for HLA-DR were five times more numerous in LE than those in non-LE cases and were distributed densely in the degenerated white matter but sparsely in the subcortical arcuate fibers. CD4- and CD8-positive lymphocytes were 9 and 15 times more plentiful, respectively, in LE cases; they aggregated in the expanded Virchow-Robin spaces and frequently infiltrated the neural parenchyma. An intimate association of T cells with macrophages, and the expression of leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1), accessory molecules in antigen presentation, were observed in each cell in the region of macrophage clusters. These results indicate that expression of MHC antigen is accompanied by cell adhesion molecules and by infiltration of T cells in a heterogeneous group in leukoencephalopathy and suggests their immunocompetence, although it may be secondary to destruction of myelin.
我们在此报告白质脑病（LE）中巨噬细胞和小胶质细胞异质性群体中T细胞浸润以及主要组织相容性复合体（MHC）II类抗原的弥漫性表达情况。在LE中，对HLA - DR呈阳性反应的小胶质细胞数量是非LE病例的五倍，密集分布于变性的白质中，而在皮质下弓状纤维中分布稀疏。在LE病例中，CD4和CD8阳性淋巴细胞分别多9倍和15倍；它们聚集在扩大的Virchow - Robin间隙中，并经常浸润神经实质。在巨噬细胞簇区域的每个细胞中都观察到T细胞与巨噬细胞的紧密关联，以及白细胞功能相关抗原 - 1（LFA - 1）和细胞间黏附分子 - 1（ICAM - 1）（抗原呈递中的辅助分子）的表达。这些结果表明，在白质脑病中，MHC抗原的表达伴随着细胞黏附分子和T细胞在异质性群体中的浸润，并提示它们具有免疫活性，尽管这可能继发于髓鞘破坏。
