Witte W, Cuny C, Claus H
Robert Koch-Institute, Federal Health Office, Wernigerode, Germany.
Zentralbl Bakteriol. 1993 Jun;278(4):510-7. doi: 10.1016/s0934-8840(11)80821-2.
Methicillin-resistant S. aureus with quinolone-resistance (QR-MRSA) isolated in Germany from three outbreaks of nosocomial infections and from sporadic nosocomial infections in five hospitals exhibited different SmaI-restriction patterns of their genomic DNA. Phage-typing and determination of plasmid profiles performed in parallel confirmed this differentiation, with one exception. These results indicate that there is obviously no overregional spread of one particular QR-MRSA clone and that quinolone resistance has developed independently in different MRSA.
在德国，从五家医院的三次医院感染暴发以及散发性医院感染中分离出的耐喹诺酮的耐甲氧西林金黄色葡萄球菌（QR-MRSA），其基因组DNA呈现出不同的SmaI限制性酶切图谱。同时进行的噬菌体分型和质粒图谱测定证实了这种差异，但有一个例外。这些结果表明，显然不存在某一特定QR-MRSA克隆的跨地区传播，并且喹诺酮耐药性在不同的耐甲氧西林金黄色葡萄球菌中是独立产生的。
