McCann U D, Ricaurte G A
Section on Anxiety and Affective Disorders, Bethesda, MD 20892.
J Clin Psychopharmacol. 1993 Jun;13(3):214-7.
(+/-)3,4-Methylenedioxymethamphetamine (MDMA), a synthetic amphetamine derivative used recreationally by humans, damages brain serotonin neurons in experimental animals. In preclinical studies, serotonin reuptake inhibitors block MDMA-induced serotonin release; they also block MDMA neurotoxicity. Whether serotonin reuptake inhibitors also block MDMA's psychoactive effects in humans has not been established. Reported herein are four individuals who describe their experiences after ingesting fluoxetine, a potent and selective serotonin reuptake inhibitor, before MDMA ingestion. Their reports indicate that fluoxetine does not block MDMA's reinforcing subjective effects and raise the possibility that MDMA's psychoactive effects may be separable from its neurotoxic actions.
（±）3,4-亚甲基二氧甲基苯丙胺（摇头丸）是一种人类用于娱乐的合成苯丙胺衍生物，在实验动物中会损害脑血清素神经元。在临床前研究中，血清素再摄取抑制剂可阻断摇头丸诱导的血清素释放；它们还能阻断摇头丸的神经毒性。血清素再摄取抑制剂是否也能阻断摇头丸对人类的精神活性作用尚未确定。本文报告了四名个体，他们描述了在服用摇头丸之前摄入强效选择性血清素再摄取抑制剂氟西汀后的经历。他们的报告表明，氟西汀不会阻断摇头丸增强主观效应的作用，并增加了摇头丸的精神活性作用可能与其神经毒性作用相分离的可能性。
