双相情感障碍中的红细胞膜结构：一项非重复研究。

Erythrocyte membrane structure in bipolar affective disorder: a non-replication.

作者信息

Nurnberger J, Miller M, Bowman E, Sullivan J, Brittain H, Lawrence D, York C

机构信息

Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis 46202-4887.

出版信息

J Affect Disord. 1993 Jun;28(2):91-4. doi: 10.1016/0165-0327(93)90037-k.

DOI:10.1016/0165-0327(93)90037-k

PMID:8102624

Abstract

Fifteen bipolar patients were compared with sixteen controls in an attempt to replicate the findings of Pettegrew et al. in 1982 of decreased fluidity in the hydrocarbon core of the erythrocyte membrane. No significant differences were seen between groups. The present control group shows very similar membrane characteristics to the original control series; however, the bipolar patient group is not similar. Possible explanations are discussed.

摘要

为了重现佩特格鲁等人1982年关于红细胞膜烃核流动性降低的研究结果，对15名双相情感障碍患者和16名对照组进行了比较。两组之间未发现显著差异。目前的对照组显示出与原始对照组系列非常相似的膜特性；然而，双相情感障碍患者组并不相似。文中讨论了可能的解释。