Browne M, Lapierre Y D, Hrdina P D, Horn E
Affective Disorders Clinic, Royal Ottawa Hospital, Ontario, Canada.
Int Clin Psychopharmacol. 1990 Apr;5(2):103-10. doi: 10.1097/00004850-199004000-00004.
This paper reports a double-blind cross-over study (1) to investigate the efficacy of lithium carbonate to produce rapid relief of major depression in patients who were previously unresponsive to at least 4 weeks of antidepressant therapy; (2) to study the effect of acute lithium administration on antidepressant blood levels. In contrast to other studies, lithium was found to be no more effective than placebo. The effect of lithium adjunct on antidepressant levels was not significant.
（1）调查碳酸锂对先前至少4周抗抑郁治疗无反应的患者产生快速缓解重度抑郁的疗效；（2）研究急性给予锂对抗抑郁药血药浓度的影响。与其他研究不同，发现锂并不比安慰剂更有效。锂辅助治疗对抗抑郁药浓度的影响不显著。
