Oka Y, Katagiri H, Yazaki Y, Murase T, Kobayashi T
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Lancet. 1993 Aug 28;342(8870):527-8. doi: 10.1016/0140-6736(93)91649-7.
Autoimmunity is thought to lead to islet-cell-antibody (ICA) formation in diabetes mellitus. However, we found a mitochondrial gene mutation at nucleotide pair 3243 in 3 of 27 Japanese ICA-positive, initially non-insulin-dependent diabetic patients. All 3 progressed to insulin-dependency within 13-31 months, whereas 5 of the other 24 are non-insulin-dependent after 54-90 months. ICA, at least in these 3 patients, may follow gradual beta-cell destruction due to mitochondrial gene mutation, although the possibility of beta-cells with the mutation being susceptible to autoimmune destruction cannot be excluded.
自身免疫被认为会导致糖尿病中胰岛细胞抗体（ICA）的形成。然而，我们在27例日本ICA阳性、最初为非胰岛素依赖型糖尿病患者中的3例发现了核苷酸对3243处的线粒体基因突变。这3例患者均在13 - 31个月内进展为胰岛素依赖型，而其他24例中的5例在54 - 90个月后仍为非胰岛素依赖型。ICA，至少在这3例患者中，可能是由于线粒体基因突变导致β细胞逐渐破坏的结果，尽管不能排除携带该突变的β细胞易受自身免疫破坏的可能性。
