Schrijvers D, Wanders J, Dirix L, Prove A, Vonck I, van Oosterom A, Kaye S
Department of Medical Oncology, Antwerp University Hospital, Edegem, Belgium.
Ann Oncol. 1993 Aug;4(7):610-1. doi: 10.1093/oxfordjournals.annonc.a058599.
In phase II studies of the EORTC-ECTG, acute hypersensitivity reaction, edema and skin toxicity were important side effects of docetaxel (TaxotereTM).
Fifty patients with solid tumors were treated with docetaxel at the University Hospital of Antwerp. Of these, 28% developed an acute hypersensitivity reaction and 20% edema. Twelve and three hours before the next docetaxel administrations those with the acute hypersensitivity reaction were subsequently pretreated orally with 32 mg of methylprednisolone, 10 mg of cetirizine and 1 mg of ketotifen.
The acute hypersensitivity reaction could be completely blocked in all but in 1 of 14 patients, and this pretreatment schedule had an important prophylactic effect on edema formation. Skin toxicity was successfully treated with an ointment of glycerin and chlorhexidine.
在欧洲癌症研究与治疗组织实体瘤协作组（EORTC-ECTG）的II期研究中，急性过敏反应、水肿和皮肤毒性是多西他赛（泰索帝TM）的重要副作用。
50例实体瘤患者在安特卫普大学医院接受多西他赛治疗。其中，28%出现急性过敏反应，20%出现水肿。在下次多西他赛给药前12小时和3小时，对出现急性过敏反应的患者随后口服32毫克甲泼尼龙、10毫克西替利嗪和1毫克酮替芬进行预处理。
除14例患者中的1例之外，急性过敏反应在所有患者中均可被完全阻断，且这种预处理方案对水肿形成具有重要的预防作用。皮肤毒性通过甘油和氯己定软膏成功治愈。
