Kogire M, Inoue K, Doi R, Sumi S, Takaori K, Yun M, Hosotani R, Tobe T
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Eur J Surg. 1993 May;159(5):283-6.
To describe the secretory responses to physiological stimulation of the exocrine pancreas after partial pancreatectomy in conscious animals.
Controlled study.
Thirteen mongrel dogs.
Partial pancreatectomy (n = 4), and creation of gastric and pancreatic (Herrera) fistulas (n = 13). Collections of duodenal juice at 15 minute intervals after an oral meal or during intraduodenal infusion of sodium oleate, and blood samples.
Protein concentration in duodenal juice and cholecystokinin 33/39 concentrations in plasma one and three months after partial pancreatectomy, and secretion of fluid by the pancreas.
Pancreatic protein output after a meal was significantly reduced at one and three months in dogs after partial pancreatectomy compared with control animals. Protein output in response to an intraduodenal infusion of oleate was also reduced at both time points. In contrast, secretion of fluid after a meal or during infusion of oleate was unchanged by removal of the distal lobe. There was no correlation between the effects of partial pancreatectomy on protein output and plasma concentrations of cholecystokinin 33/39.
Pancreatic exocrine deficiency, particularly the reduction in secretion of protein, results directly from the partial pancreatectomy and persists for at least three months after the operation.
描述清醒动物部分胰腺切除术后外分泌胰腺对生理刺激的分泌反应。
对照研究。
13只杂种犬。
部分胰腺切除术（n = 4），以及建立胃和胰腺（埃雷拉）瘘管（n = 13）。口服餐后或十二指肠内输注油酸钠期间每隔15分钟收集十二指肠液，并采集血样。
部分胰腺切除术后1个月和3个月时十二指肠液中的蛋白质浓度以及血浆中胆囊收缩素33/39的浓度，以及胰腺的液体分泌量。
与对照动物相比，部分胰腺切除术后1个月和3个月时，犬餐后胰腺蛋白质输出量显著降低。在这两个时间点，十二指肠内输注油酸钠后的蛋白质输出量也降低。相比之下，切除胰腺远端叶后，餐后或输注油酸钠期间的液体分泌量未发生变化。部分胰腺切除术对蛋白质输出量的影响与血浆胆囊收缩素33/39浓度之间无相关性。
胰腺外分泌功能不足，尤其是蛋白质分泌减少，直接源于部分胰腺切除术，且术后至少持续3个月。
