Faichney A, Chey W Y, Kim Y C, Lee K Y, Kim M S, Chang T M
Gastroenterology. 1981 Sep;81(3):458-62.
The effects of sodium oleate and triglyceride infused into the duodenum of dogs with chronic pancreatic fistulas on pancreatic secretion and plasma immunoreactive secretin were investigated. The responses were compared with those following intravenous secretin infusions. Oleate markedly increased pancreatic water and bicarbonate secretion in a dose-related fashion, and these increases were accompanied by a small, but significant rise in the level of circulating immunoreactive secretin. No change in pancreatic secretion or in plasma secretin level was observed by the administration of triglyceride. Comparison of the bicarbonate response after oleate infusion with that after secretin administration suggests that the pancreatic stimulatory effect of intraduodenal sodium oleate is mediated to a major extent by the release of endogenous secretin.
研究了将油酸钠和甘油三酯注入患有慢性胰瘘的狗的十二指肠后，对胰腺分泌和血浆免疫反应性促胰液素的影响。将这些反应与静脉注射促胰液素后的反应进行了比较。油酸盐以剂量相关的方式显著增加了胰腺的水分和碳酸氢盐分泌，并且这些增加伴随着循环免疫反应性促胰液素水平的小幅但显著升高。给予甘油三酯后，未观察到胰腺分泌或血浆促胰液素水平的变化。油酸盐输注后与促胰液素给药后的碳酸氢盐反应比较表明，十二指肠内油酸钠的胰腺刺激作用在很大程度上是由内源性促胰液素的释放介导的。
