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关于使用比哈西特治疗患者的一些临床和生化观察的初步报告。

Preliminary report on some clinical and biochemical observations in patients treated with Bilharcid.

作者信息

Faríd F, Moussà A H, Abulfadl A M, El-Raziky E H, Adham I

出版信息

Egypt J Bilharz. 1975;2(1):31-6.

PMID:810341
Abstract

Tartar emetic (potassium antimony tartrate) has been used since a long time as the drug of choice for the treatment of Bilharziasis in Egypt. This drug, though effective, has severe side effects. A newly synthesized trivalent antimony preparation (piperazine di-antimonyl tratrate) Bilharcid, has proved in animal experiments to be less toxic, more effective, and having little side effects. The drug was tried in various schemes on various age groups of patients infected with S. haematobium. Control cases were treated with tartar emetic. Urine analysis was done for the detection of living or dead ova before and after treatment. E.C.G., alkaline phosphatase, serum transaminase, lactic dehydrogenase, and urea tests were done before and after treatment. Follow up studies were recorded for three months after treatment. Results are presented in the full text.

摘要

吐酒石(酒石酸锑钾)长期以来一直是埃及治疗血吸虫病的首选药物。这种药物虽然有效,但有严重的副作用。一种新合成的三价锑制剂(哌嗪二锑酒石酸盐)“比哈尔西德”,在动物实验中已证明毒性较小、更有效且副作用小。该药物在感染埃及血吸虫的不同年龄组患者中采用了各种方案进行试验。对照组用吐酒石治疗。治疗前后进行尿液分析以检测活卵或死卵。治疗前后进行心电图、碱性磷酸酶、血清转氨酶、乳酸脱氢酶和尿素检测。治疗后进行了三个月的随访研究。结果在全文中呈现。

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