铅中毒是否反映了细胞膜脂肪酸组成的改变？
Is lead toxicosis a reflection of altered fatty acid composition of membranes?
作者信息
Donaldson W E, Knowles S O
机构信息
Department of Poultry Science, North Carolina State University, Raleigh 27695-7608.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Mar;104(3):377-9. doi: 10.1016/0742-8413(93)90003-4.
PMID:8103427
Abstract
- The premise of this review is that many of the biological effects of Pb are reflection of tissue peroxidation. 2. Enhanced tissue levels of arachidonic acid in Pb toxicosis appear to be involved in the peroxidative changes. 3. The altered arachidonate metabolism may be related to changes in membrane structure and function. 4. The induction of enhanced glutathione levels in animal tissues by Pb may afford protection from peroxidative damage.
摘要
- 本综述的前提是，铅的许多生物学效应是组织过氧化的反映。2. 铅中毒时组织中花生四烯酸水平的升高似乎与过氧化变化有关。3. 花生四烯酸代谢的改变可能与膜结构和功能的变化有关。4. 铅诱导动物组织中谷胱甘肽水平升高可能提供对过氧化损伤的保护。
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