兔尿道α-肾上腺素能受体的药理学评估

Pharmacological evaluation of the alpha-adrenoceptors of the rabbit urethra.

作者信息

Chen H I, Hu P, Fan P L, Brading A F

机构信息

Department of Urology/Surgery, 804 Army General Hospital, Taoyuan, Taiwan, ROC.

出版信息

Eur Urol. 1993;24(1):144-7. doi: 10.1159/000474282.

DOI:10.1159/000474282

PMID:8103455

Abstract

Nerve-mediated responses of the rabbit urethral smooth muscles were studied using electrical stimuli of short duration to selectively stimulate the intramural nerves. The nature of the responses to exogenously applied adrenergic agonists and its antagonists were also examined. The results confirmed that the rabbit urethral smooth muscle contains both subtypes of alpha-adrenoceptors and the nerve-mediated contraction of the rabbit urethra is of adrenergic nature and mediated mainly via alpha 1-adrenoceptors.

摘要

使用短时长电刺激选择性刺激壁内神经，研究了兔尿道平滑肌的神经介导反应。还检测了对外源性应用的肾上腺素能激动剂及其拮抗剂的反应性质。结果证实，兔尿道平滑肌含有α-肾上腺素能受体的两种亚型，兔尿道的神经介导收缩具有肾上腺素能性质，主要通过α1-肾上腺素能受体介导。